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In "The Amazing Spider-Man" film, after being bitten by that spider at OsCorp, Peter Parker (Andrew Garfield), is astonished, as well as understandably frightened, by his sudden new abilities. Instead of being klutzy, as he'd previously been all his life, Peter is now nimble, agile, and very strong. Not to mention he can stick to the ceiling!
Of course, everyone else on that subway car is shocked, too, but none more so than Peter himself. It's the beginning of Peter Parker's new life as Spider-Man.