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In this world, there exists people with special abilities to manipulate objects and transform one object into another. These people are known as alchemists. This process does come with a cost though, the basic law of alchemy states that to gain something you have to sacrifice something of the same value.
The main character is the famous alchemist Edward Elric – also known as the Fullmetal Alchemist – who almost lost his little brother, Alphonse, in an accident. Edward managed to contain his brother’s soul in a large suit of armor. While he did manage to save his brother’s life, he had to pay a great price himself.
To get back what they’ve lost, the brothers embark on a journey to find the Philosophers Stone that is said to amplify the powers of an alchemist enormously.
Wikipedia entry: http://en.wikipedia.org/wiki/Fullmetal_Alchemist
Read the manga online here: http://www.onemanga.com/Full_Metal_Alchemist/